Symbol
Name
ID

Pdx1
pancreatic and duodenal homeobox 1
MGI:102851

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Neonatal insulin-dependent diabetes mellitus	Maturity-onset diabetes of the young	Type II diabetes mellitus	Pancreatic aplasia	Pancreatic hypoplasia	Exocrine pancreatic insufficiency
Disease(s) Associated with PDX1	Neonatal insulin-dependent diabetes mellitus	Maturity-onset diabetes of the young	Type II diabetes mellitus	Pancreatic aplasia	Pancreatic hypoplasia	Exocrine pancreatic insufficiency
maturity-onset diabetes of the young type 4
pancreatic agenesis
type 2 diabetes mellitus

Mouse Phenotypes

abnormal pancreatic islet cell apoptosis

abnormal pancreatic beta cell apoptosis

increased pancreatic beta cell apoptosis

abnormal pancreatic beta cell differentiation

decreased pancreatic beta cell proliferation

increased pancreatic alpha cell proliferation

abnormal stomach enteroendocrine cell morphology

abnormal pancreatic acinar cell morphology

abnormal pancreatic duct morphology

absent Brunner's glands

exocrine pancreatic insufficiency

endocrine/exocrine gland phenotype

abnormal bile duct development

abnormal pancreatic islet morphology

abnormal PP cell morphology

increased PP cell number

decreased pancreatic alpha cell mass

increased pancreatic alpha cell number

decreased pancreatic beta cell mass

decreased pancreatic beta cell number

abnormal pancreatic delta cell morphology

increased pancreatic delta cell number

abnormal pancreatic epsilon cell morphology

decreased pancreatic islet number

abnormal pancreatic islet size

small pancreatic islets

pancreatic islet hypoplasia

disorganized pancreatic islets

abnormal pancreas development

abnormal pancreas morphology

decreased pancreas weight

small pancreas

pancreas hypoplasia

absent pancreas

increased glucagon secretion

abnormal pancreatic beta cell physiology

decreased amylin secretion

decreased insulin secretion

abnormal pancreatic endocrine progenitor cell physiology

pancreas inflammation

Availability

Mouse Genotype

Pdx1^tm1.1Stof/Pdx1^tm1.1Stof

Pdx1^tm1Cvw/Pdx1^tm1Cvw

Pdx1^tm1Ted/Pdx1^tm1Ted

Pdx1^tm2Cvw/Pdx1^tm2Cvw

Pdx1^tm3Cvw/Pdx1^tm3Cvw

Pdx1^tm1.1Stof/Pdx1⁺

Pdx1^tm1Cvw/Pdx1⁺

Pdx1^tm1Cvw/Pdx1^tm1.1Stof

Pdx1^tm1Ted/Pdx1⁺

Pdx1^tm2Cvw/Pdx1⁺

Pdx1^tm2Cvw/Pdx1^tm3Cvw

Pdx1^tm3Cvw/Pdx1⁺

Pdx1^tm1Heed/Pdx1^tm1Heed
Tg(Ins2-cre)1Heed/0 (conditional)

Pdx1^tm1Cvw/Pdx1^tm4Cvw
Tg(Ins2-cre)25Mgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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